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. 2017 Mar 3;292(16):6728–6743. doi: 10.1074/jbc.M117.778308

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Figure 13. — Three phylum-specific segments (magenta) mapped on the structure of C. albicans CYP51 (semitransparent magenta). A, β5 hairpin is unique for fungal CYP51 and forms the proximal surface of the P450 molecule. B, similar to protozoan and opposite to human CYP51, the I-helix in the C. albicans enzyme does not have a loop-like region in the middle portion. C, FG-loop in C. albicans CYP51 is shorter and has only one α-helical region (F″), and the G′-helix is unique for the protozoan enzymes. Superimposition with the structure of T. brucei CYP51 (PDB code 3G1Q) is shown in semi-transparent gold. View is from distal face of the P450 molecule.