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. 2016 Jun 16;17(6):328–334. doi: 10.1038/gene.2016.27

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Expression of transcription factor ratios in the peripheral blood of HCV-treated subjects (n=24) analysed for differences in IFNL3 genotype. (a) Ratios show a TBX21 (Th1/NK)-dominant effect associated with the IFNL3 responder genotype (rs8099917 TT and rs12979860 CC). (b) Ratio of TBX21/GATA3 (Th1, NK/Th2) showing significant differences for rs8099917 (P=0.017) and for rs12979860 (P=0.038). (c) Ratio of TBX21/RORC (Th1, NK/Th17) showing significant differences for rs8099917 (P=7.4 × 10⁻³).