Table 2. Composition of the 6-GPS.
| Signature | ROEs (Ra>Rb) | β | P-value | FDR | C-index |
|---|---|---|---|---|---|
| Gene pair 1 | CHTOP>CAPN2 | 1.22 | 6.37E-05 | 1.89E-03 | 0.63 |
| Gene pair 2 | MRPL4>AXL | 0.98 | 4.12E-05 | 1.70E-03 | 0.60 |
| Gene pair 3 | SLC19A1>NREP | 1.09 | 2.19E-03 | 1.43E-02 | 0.59 |
| Gene pair 4 | PUS1>LTBP2 | 0.61 | 8.74E-03 | 3.39E-02 | 0.57 |
| Gene pair 5 | MCM2>IFRD2 | 0.66 | 1.18E-02 | 3.89E-02 | 0.57 |
| Gene pair 6 | SLC19A1>WWC2 | 1.20 | 9.92E-05 | 2.41E-03 | 0.56 |
Note: ROEs represent the relative expression ordering of gene pair (Ra>Rf); β and P-value are the statistics calculated from the univariate Cox regression model. β represents the risk coefficient of the REO for gene pair (a, b), where β>0 indicates that Ra> Rb is a risk factor, otherwise a protective factor; P-value represents the significance of the REO for gene pair (a, b). All the P-values were adjusted using the Benjamini–Hochberg procedure.