Table 3. Univariate and multivariate Cox regression analysis for the GSE39582 data set.
| Characteristics |
Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| HRa (95% CI) | P-value | HR (95% CI) | P-value | |
| 6-GPS (low risk(ref)/high risk) | 3.61 (2.20,5.95) | 7.26E-08 | 3.05 (1.66,5.60) | 3.36E-04 |
| Tumor stage (II(ref)/III) | 1.43 (0.83, 2.46) | 2.00E-01 | 1.56 (0.78, 3.10) | 2.09E-01 |
| Gender (femal (ref)/male) | 1.05 (0.67, 1.66) | 8.30E-01 | 0.74 (0.42, 1.33) | 3.16E-01 |
| Age (⩽70 (ref)/>70) | 1.03 (0.62, 1.71) | 9.00E-01 | 0.78 (0.40, 1.53) | 4.73E-01 |
| Tumor location (proximal (ref)/distal) | 1.38 (0.83, 2.29) | 2.10E-01 | 1.84 (0.93, 3.67) | 8.16E-02 |
| MMR status (pMMR (ref)/dMMR) | 0.80 (0.29, 2.20) | 6.70E-01 | 1.74 (0.49, 6.23) | 3.94E-01 |
| BRAF mutation (WT (ref)/M) | 0.71 (0.17, 2.93) | 6.40E-01 | 0.62 (0.073, 5.25) | 6.61E-01 |
| KRAS mutation (WT (ref)/M) | 1.26 (0.78, 2.04) | 3.40E-01 | 1.35 (0.73, 2.50) | 3.44E-01 |
Abbreviations: dMMR, MMR-deficient; HR, hazard ratio; M, mutation; MMR, mismatch repair; pMMR, MMR-proficient; ref, reference group in calculation of HR; WT, wild-type.
Bold parts indicates the Cox regression analysis results for the 5-FU-based therapy prognostic gene pair signature.