Table 2. BPA affects ATP content in pancreatic islets cultured in the presence of 25 mM glucose.
BPA | Glucose 25 mmol/l |
Normalized on vehicle-treated cells |
Normalized on glucose-treated cells |
||||
---|---|---|---|---|---|---|---|
Relative luminescence level fold change | St. Dev. | P-value | Relative luminescence level fold change | St. Dev. | P-value | ||
Vehicle | − | 1.000 | 0.247 | ||||
10−6 M | − | 0.983 | 0.330 | 0.922 | |||
10−9 M | − | 1.047 | 0.244 | 0.745 | |||
− | + | 0.261 | 0.314 | 0.001 | 1.000 | 0.474 | |
10−6 M | + | 0.088 | 0.107 | 0.0001 | 0.418 | 0.177 | 0.018* |
10−9 M | + | 0.102 | 0.103 | 0.0001 | 0.348 | 0.137 | 0.009** |
Data are reported as fold change values calculated as ratio between average luminescence/total protein content in treated and control cells. *P-value <0.05; **P-value <0.01; compared with glucose-only-treated islets