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. 2016 Feb 18;7(2):e2101. doi: 10.1038/cddis.2015.347

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Inhibition of αvβ5 integrin reduces astrocyte loss in STZ-induced diabetic mice (DM). Anti-αvβ5-integrin-neutralizing antibody (Anti-αvβ5 Ab, 1 μg) or PBS was intravitreally injected to 2-week-old DM. Retinal astrocyte was evaluated 1 week after the injection in 3-week-old DM. (a) Focal astrocyte loss shown in diabetic retina (PBS) is rescued in anti-αvβ5 Ab-injected DM (original magnification × 400; scale bar, 100 μm). (b) Relative astrocyte coverage (%) is calculated by colocalized area of astrocyte and vessel per IB4⁺ vascular area and normalized to the value of control mice. The sample size for each group is indicated in the bar graph. The bar graph represents mean±S.E.M.; *P<0.001 by Student's t-test