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. 2016 Feb 18;7(2):e2105. doi: 10.1038/cddis.2015.374

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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High-throughput screening of 21 608 small molecules on prelamin A maturation. (a) Prelamin A and Hoechst immunostaining in HGPS MSCs treated with FTIs. (b) Primary screen cell-based assay for prelamin A localization. Dot plot representation of the effects of the 21 608 compounds on prelamin A maturation process and cell viability. (c) Dose-response experiments of the 11 prelamin A modulators identified. Each chart represents cell viability (in red) and percentage of prelamin A-positive nuclei (in blue). Each point represents the mean±S.D. of the percentage of eight replicates