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. 2016 Feb 18;7(2):e2105. doi: 10.1038/cddis.2015.374

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Copyright © 2016 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effect of the 11 validated compounds on farnesylation process. (a) Western blot analysis of Lamin A, lamin C, progerin, prelamin A and HDJ2 expression in HGPS MSCs following 48 h of treatment with each of the 11 validated compounds. (b) GFP localization of HGPS MSCs overexpressing hRas-GFP following 48 h of treatment with each of the 11 validated compounds. Scale bar represents 50 μm. (c) Quantification of the percentage of HGPS MSCs presenting a cytoplasmic (unfarnesylated) localization of GFP following 48 h of treatments with each of the 11 prelamin A modulators. Each chart represents the mean±S.D. of three independent experiments