Table 3. Clusters Showing Significant Correlation Between FA and Symptom Counts in the ADHD Group.
| Cluster Index | White Matter Tractsa (Size of Overlap>10 voxels) | Size (voxels)b | MNI Coordinate of the Peak voxel (x; y; z;) | P-valuec |
|---|---|---|---|---|
| FA clusters with significantly positive correlation with the Hyperactivity/impulsivity symptom counts in ADHD participants | ||||
| 1 | Body and splenium of corpus callosum, cerebral peduncle (R), anterior limp of internal capsule (R), retrolenticular part of internal capsule (R), superior corona radiata (R), posterior corona radiata (R), posterior thalamic radiation (R), stratum (including inferior longitudinal fasciculus & inferior fronto-occipital fasciculus) (R), fornix (cres)/stria terminalis (R), superior longitudinal fasciculus (R), superior fronto-occipital fasciculus (R), tapetum (R) | 3943 | 33; −60;3 | 0.027 |
| 2 | Genu and body of corpus callosum, anteior corona radiata (R), Superior corona radiata (R) | 1050 | 18; 22; 25 | 0.023 |
| 3 | Posterior thalamic radiation (L), sagittal stratum (including inferior longitudinal fasciculus & inferior fronto-occipital fasciculus) (L) | 171 | −35; −57; −1 | 0.044 |
| 4 | Anterior corona radiata (L) | 139 | −27; 21; 16 | 0.048 |
| 5 | Posterior corona radiata (L) | 120 | −24; −54; 24 | 0.037 |
| 6 | Anterior corona radiata (L) | 98 | −21; 29; 1 | 0.047 |
| 7 | Forceps minord | 52 | −18; 51; 12 | 0.049 |
a
White matter tracts as defined with the JHU ICBM-DTI-81 White-Matter Labels.
b
Cluster size >50 voxels.
c
P<0.05, FWE-corrected, controlling for gender, age and scan acquisition protocol.
d
Region not classified in the ICBM-DTI-81 labels and thus the JHU White-Matter Tractography Atlas was used here.