Figure 2. Thermogenic adipocytes modulate TRL and HDL levels in normo- and hyperlipidemic mice.

Mice were either mock-treated (Mock), exposed to 4 °C (Cold) or treated with CL316,243 (CL) for 7 days. (a) Total plasma TG and (b) cholesterol as well as (c–h) corresponding cholesterol FPLC profiles from plasma of (c,f) C57BL/6J, (d,g) Apoa5^−/− and (e,h) E3L.CETP mice. For FPLC analysis, individual plasma samples were analysed and cholesterol levels were determined n each fraction (n=4–5 per group). Values are means±s.e.m. Significance was calculated using unpaired two-tailed Student's t-test. *P<0.05, versus mock.