Scheme 2.
Synthesis of first generation compounds 4a–j. Reagents and conditions: (a) HATU, TEA, CH2Cl2, r.t., 5 h.; (b) TFA/CH2Cl2 95:5, r.t., 2 h.; (c) LiOH, THF/H2O 4:1, r.t., overnight.
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