Table 3.

Factors associated with new onset proteinuria^a (n = 455)

	Crude		Adjusted
Variable	HR (95%CI)	P value	HR (95%CI)	P value
Age at initiation, year
50-64 vs 17-49	1.16 (0.76 − 1.75)	0.04	1.05 (0.68 − 1.62)	0.84
≥65 vs 17-49	2.22 (1.19 − 4.15)	0.04	1.75 (0.90 − 3.39)	0.10
Male vs female patients	0.61 (0.42 − 0.90)	0.02	0.67 (0.42 − 1.06)	0.09
Baseline eGFR < 60 vs ≥60 mL/min/1.73 m2	1.62 (1.15 − 2.27)	0.006	1.28 (0.89 − 1.85)	0.18
Hepatitis B	1.02 (0.72 − 1.44)	0.63	1.23 (0.78 − 1.95)	0.37
Hepatitis C	1.30 (0.90 − 1.87)	0.02	1.26 (0.80 − 1.97)	0.32
Alcoholism	0.64 (0.36 − 1.14)	0.74	0.79 (0.42 − 1.47)	0.45
Decompensated liver cirrhosis	1.24 (0.89 − 1.74)	0.20	1.21 (0.84 − 1.74)	0.32
HCC	1.02 (0.73 − 1.44)	0.29	1.06 (0.72 − 1.57)	0.76
Diabetes mellitus	2.32 (1.64 − 3.28)	<.0001	1.91 (1.32 − 2.77)	<.001
New onset diabetes mellitusb	2.77 (1.96 − 3.90)	<.0001	2.34 (1.62 − 3.38)	<.0001
CNI prior use	2.30 (0.73 − 7.27)	0.15	2.27 (0.69 − 7.43)	0.18
CNI use after	0.69 (0.32 − 1.48)	0.33	0.67 (0.29 − 1.54)	0.35
SRL trough level < 3 months	0.97 (0.91 − 1.03)	0.30	1.01 (0.95 − 1.07)	0.81

^aEvent of new onset proteinuria was identified within 1 year during the follow-up among a subgroup of patients without proteinuria presence at baseline

^bNew onset diabetes mellitus anytime in the follow-up period