Table 4.
Pharmacokinetic parameters of verticillin A following IP, IV, and PO administration to mice
| Parameter | IV, 1 mg/kg (1.43 μmol/kg) | IP, 3 mg/kg (4.30 μmol/kg) | PO, 3 mg/kg (4.30 μmol/kg) |
|---|---|---|---|
| Cmax (nM) | 72.9 | 110 | 9.13 |
| AUClast (nM·h) | 152 | 775 | 39.9 |
| AUC0-∞_obs | 290 | 970 | 43.7 |
| T1/2 (h) | 19.91 | 10.92 | 1.75 |
| Tmax (h) | 0.08 | 0.5 | 0.5 |
| CL (L/h/kg)a | 4.94 | 2.61 | 98.45 |
| Vd (L/kg)b | 142 | 70 | 249 |
| F (%) | 100 | 170 | 8.76 |
a
: Clearance; CL/F for IP and PO administration
b
: Volume of distribution; CL/F for IP and PO administration
AUC0-∞_obs, area under the observed concentration-time curve extrapolated to infinity