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. 2017 Apr 21;7:46461. doi: 10.1038/srep46461

Figure 5. TLR signaling is downregulated by CN-105.

Figure 5

(A) A schematic of the signaling pathway proposed for sterile inflammation post injury. Green arrows indicate upregulation and red arrows downregulation of genes 24 hours after TBI.(B) Graphic representation of genes 24 hours post TBI demonstrating fold change compared to sham control.(C) CN-105 modifies the post-injury inflammatory response. Arrows indicate reduced upregulation(green) and reduced downregulation(red) of gene expression when TBI injured mice are treated with CN-105 as compared to vehicle.(D) Graphic representation of differential gene expression 24 hours post TBI demonstrating fold change in gene expression of CN-105 treated mice normalized to vehicle treated TBI mice.