Figure 4. Effect of IL-6 inhibition on insulin tolerance and clearance after acute exercise in mice.

Blood glucose (A) and AUC of blood glucose (B) before and 5, 10, 15, 20, 25, 30 and 60 min after administration of 0.75 U kg⁻¹ insulin. Plasma insulin (C) and AUC of plasma insulin (D) at 0, 5, 15, 30 and 60 min during ipITT. CTL, control mice; EXE, exercised mice; and EXE + TCZ, exercised mice treated with 2 mg kg⁻¹ Tocilizumab 1-h before the exercise protocol. Data are presented as the mean ± S.E.M. n = 6. *p ≤ 0.05 vs CTL and ^#p ≤ 0.05 vs EXE.