Table 1.

Significantly expressed miRNAs deregulated in PTC compared with adjacent normal tissue (PTC-T vs PTC-N, FDR < 0.05) and with control, noncancerous thyroid (PTC-T vs NN, FDR < 0.05)

miRNA	Mean Expression in PTC-T	Mean Expression in PTC-N	Mean Expression in NN	Paired P Value, T vs N	Paired FDR, T vs N	Fold Change, T vs N	P Value, T vs NN	FDR T, vs NN	fold change T vs. NN
hsa-miR-146b-3p	119	11	6.8	.00142	0.031	10.8	.00002	0.001	17.5
hsa-miR-146b-5p	5346	507	258	.00116	0.027	10.5	.00001	0.001	20.7
hsa-miR-891a	12	1.6	2.0	.00214	0.031	7.68	.00705	0.027	5.92
hsa-miR-551b-3p	713	109	102	.00101	0.025	6.53	.00011	0.002	7
hsa-miR-187–3p	14	2.8	2.6	.00176	0.031	5.10	.00036	0.004	5.58
hsa-miR-221–5p	356	78	71	.0008	0.024	4.57	.00003	0.001	5.03
hsa-miR-147b	11	2.5	3.8	.0032	0.036	4.53	.0254	0.073	3.01
hsa-miR-21–3p	62	15	32	.00188	0.031	4.04	.02784	0.078	1.95
hsa-miR-181b-3p	7.5	1.9	2.5	.00034	0.02	3.91	.00048	0.005	2.94
hsa-miR-222–5p	123	34	35	.00359	0.039	3.63	.00022	0.003	3.51
hsa-miR-182–5p	487	185	168	.00235	0.031	2.63	.0002	0.003	2.9
hsa-miR-33b-5p	28	11	8.3	.00005	0.01	2.55	.00023	0.003	3.44
hsa-miR-203a	678	272	258	.00223	0.031	2.49	.00093	0.007	2.63
hsa-miR-183–5p	135	54	63	.00065	0.024	2.48	.00113	0.008	2.14
hsa-miR-589–5p	5.4	2.3	5.2	.00484	0.049	2.39	.87155	0.917	1.05
hsa-miR-3913–5p	4.9	2.1	3.3	.00244	0.031	2.29	.20154	0.334	1.48
hsa-miR-135b-5p	6699	3644	3512	.00079	0.024	1.84	0	0	1.91
hsa-miR-744–3p	26	18	14	.00073	0.024	1.49	.00027	0.003	1.85
hsa-miR-17–3p	122	90	75	.00072	0.024	1.35	.06266	0.142	1.62
hsa-miR-574–3p	2649	4086	5085	.0052	0.05	0.65	.00016	0.003	0.52
hsa-miR-3200–3p	3.9	6.3	5.9	.00012	0.012	0.62	.02797	0.078	0.66
hsa-let-7d-5p	2872	4688	5415	.00174	0.031	0.61	.00017	0.003	0.53
hsa-miR-130a-3p	11926	19878	14234	.00253	0.031	0.6	.65199	0.757	0.84
hsa-miR-100–5p	7424	13920	10393	.00211	0.031	0.53	.17437	0.301	0.71
hsa-miR-195–5p	1031	2019	1973	.00495	0.049	0.51	.00164	0.01	0.52
hsa-miR-532–5p	869	1777	2116	.00088	0.024	0.49	.0003	0.003	0.41
hsa-miR-585	2.2	4.4	7.1	.00179	0.031	0.49	.00164	0.01	0.3
hsa-miR-455–3p	258	537	608	.00235	0.031	0.48	.00007	0.001	0.42
hsa-miR-138–5p	2831	6088	6265	.00244	0.031	0.47	.01952	0.062	0.45
hsa-miR-1249	10	24	44	.00399	0.043	0.43	.00004	0.001	0.23
hsa-miR-145–5p	19539	48752	65418	.00055	0.024	0.4	0	0	0.3
hsa-miR-20b-5p	54	133	168	.00198	0.031	0.4	.00151	0.009	0.32
hsa-miR-1180	10	26	21	.00061	0.024	0.39	.10622	0.203	0.48
hsa-miR-652–3p	2.9	7.4	5.0	.00471	0.049	0.38	.27762	0.407	0.57
hsa-miR-1291	1.8	5.2	4.5	.00007	0.01	0.35	.00157	0.01	0.4
hsa-miR-138–1-3p	60	189	260	.00024	0.017	0.31	0	0	0.23
hsa-miR-451a	23566	76540	73460	.0015	0.031	0.31	.00441	0.019	0.32
hsa-miR-486–5p	24	77	75	.00254	0.031	0.31	.04174	0.105	0.31
hsa-miR-144–5p	138	499	535	.00023	0.017	0.28	.00073	0.006	0.26
hsa-miR-486–3p	4.2	18	24	.00001	0.002	0.23	0	0	0.17
hsa-miR-873–5p	6.6	30	29	.0009	0.024	0.22	.00678	0.027	0.23
hsa-miR-204–5p	254	1241	1041	.00275	0.033	0.2	.00423	0.019	0.24
hsa-miR-7–2-3p	128	773	981	.00292	0.034	0.17	.00065	0.006	0.13
hsa-miR-1179	29	214	229	.00214	0.031	0.14	.00102	0.008	0.13