Table 1. Body and kidney weights, and blood and urinary parameters in ALDO wild-type or ALDO systemic GC-A KO mice with or without FR167653.

	ALDO WT	ALDO WT + FR	ALDO KO	ALDO KO + FR
BW at 4 wk, g	29.1 ± 0.4	29.1 ± 0.5	28.9 ± 0.8	28.0 ± 0.5
LKW at 4 wk, mg	312 ± 13	322 ± 16	396 ± 7††	364 ± 16
LKW/BW at 4 wk, mg/g	10.75 ± 0.64	11.07 ± 0.62	13.70 ± 0.44††	13.04 ± 0.84
Serum UN, mg/dL	23.9 ± 1.9	23.9 ± 1.3	23.5 ± 3.4	24.0 ± 1.9
Serum Cr, mg/dL	0.142 ± 0.012	0.166 ± 0.017	0.166 ± 0.029	0.170 ± 0.008
Serum sodium, mEq/L	162.2 ± 1.0	160.4 ± 0.9	162.6 ± 1.3	160.2 ± 1.5
Serum potassium, mEq/L	3.02 ± 0.21	3.46 ± 0.12	3.10 ± 0.10	3.36 ± 0.22
Urinary sodium, mEq/day	2.26 ± 0.39	1.90 ± 0.09	2.87 ± 0.41	2.50 ± 0.28
Urinary potassium, mEq/day	0.49 ± 0.06	0.54 ± 0.08	0.69 ± 0.07	0.62 ± 0.04
Urinary potassium/sodium	0.246 ± 0.023	0.273 ± 0.020	0.237 ± 0.029	0.251 ± 0.019
Urinary albumin, μg/mgCr	73.9 ± 9.5	39.0 ± 4.0	9,268 ± 737††	580 ± 99**

BW, body weights; LKW, left kidney weights; UN, urea nitrogen; Cr, creatinine.

Values are expressed as the mean ± SEM for aldosterone-infused and high salt diet-fed uninephrectomized (ALDO) wild-type mice (ALDO WT; n = 5), ALDO wild-type mice with FR167653 (ALDO WT + FR; n = 5), ALDO systemic GC-A KO mice (ALDO KO: n = 5), ALDO systemic GC-A KO mice with FR167653 (ALDO KO + FR; n = 5).

^††p < 0.01, ALDO WT vs. ALDO KO.

**p < 0.01, ALDO KO vs. ALDO KO + FR.