Table 1.
Comparison of Clinical and Hormonal Characteristics of Women With PCOS and Healthy Control Women With Different AMHR2 −482 A>G Polymorphism Genotypes
| PCOS |
Control |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Total (n = 858) | AA (n = 585; 68.2%) | AG (n = 248; 28.9%) | GG (n = 25; 2.9%) | P Value | Total (n = 309) | AA (n = 234; 75%) | AG (n = 71; 23.7%) | GG (n = 4; 1.3%) | P Value | |
| Age, y | 24.02 ± 5.82 | 24.25 ± 5.73 | 23.53 ± 5.86 | 23.34 ± 7.32 | .172 | 30.85 ± 5.76 | 30.93 ± 5.94 | 30.57 ± 5.32 | 31 | .970 |
| Body mass index, kg/m2 | 26.55 ± 6.98 | 26.40 ± 6.70 | 26.88 ± 7.48 | 27.38 ± 8.78 | .875 | 27.23 ± 6.89 | 26.76 ± 6.63 | 28.72 ± 7.82 | 30.84 | .455 |
| Waist to hip ratio | 0.79 ± 0.25 | 0.78 ± 0.07 | 0.81 ± 0.46 | 0.80 ± 0.08 | .668 | 0.78 ± 0.07 | 0.78 ± 0.07 | 0.77 ± 0.07 | 0.79 | .825 |
| AMH, ng/mL | 5.88 ± 6.03c | 5.18 ± 2.61 | 5.82 ± 1.84 | 4.11 ± 2.38 | .688 | 3.12 ± 1.36 | 3.2 ± 1.39 | 2.85 ± 1.36 | ||
| FSH, mIU/mL | 5.99 ± 1.80c | 5.99 ± 1.84 | 6.05 ± 1.69 | 5.27 ± 1.62 | .197 | 6.93 ± 2.39 | 7.19 ± 2.55 | 6.13 ± 1.46 | 4.53 | .118 |
| LH, mIU/mL | 7.69 ± 5.35c | 7.78 ± 5.18 | 7.77 ± 5.88 | 4.43 ± 2.43a,b | .003 | 5.61 ± 2.71 | 5.88 ± 2.82 | 4.52 ± 2.04 | 7.96 | .085 |
| LH to FSH ratio | 1.34 ± 0.93c | 1.36 ± 0.91 | 1.34 ± 0.98 | 0.83 ± 0.41a,b | .010 | 0.85 ± 0.40 | 0.87 ± 0.42 | 0.74 ± 0.27 | 1.76 | .118 |
| DHEAS, μg/dL | 3013 ± 1315c | 3044 ± 1310 | 2986 ± 1293 | 2475 ± 1596 | .152 | 1967 ± 802 | 1955 ± 806 | 2042 ± 813 | 1323 | .660 |
| Prolactin, ng/mL | 14.20 ± 7.17 | 14.64 ± 7.32 | 13.48 ± 6.81 | 10.07 ± 4.54a | .004 | 13.49 ± 6.19 | 13.40 ± 6.42 | 13.43 ± 5.32 | 21.50 | .434 |
| Testosterone, ng/dL | 74.69 ± 29.58c | 75.36 ± 30.19 | 74.11 ± 28.53 | 63.33 ± 22.37 | .146 | 39.99 ± 11.13 | 39.78 ± 11.24 | 41.05 ± 11.09 | 33 | .741 |
| Androstenedione, ng/mL | 2.77 ± 1.07c | 2.78 ± 1.07 | 2.81 ± 1.10 | 2.33 ± 0.79 | .194 | 1.71 ± 0.47 | 1.72 ± 0.46 | 1.68 ± 0.52 | 1.41 | .775 |
| 17-Hydroxyprogesterone, ng/mL | 1.13 ± 0.56c | 1.12 ± 0.55 | 1.16 ± 0.60 | 1.06 ± 0.49 | .856 | 0.79 ± 0.39 | 0.81 ± 0.38 | 0.71 ± 0.42 | 0.52 | .448 |
| SHBG, nmol/L | 43.39 ± 26.82c | 44.15 ± 27.94 | 42.07 ± 24.48 | 37.34 ± 18.77 | .477 | 60.44 ± 32.86 | 59.65 ± 30.91 | 62.79 ± 40.42 | 70.81 | .748 |
| Free androgen index | 8.37 ± 6.83c | 8.35 ± 6.86 | 8.58 ± 7.04 | 8.37 ± 6.83 | .812 | 2.91 ± 1.65 | 2.90 ± 1.63 | 2.99 ± 1.77 | 1.62 | .523 |
Values are means ± SD. P values reflect comparisons within each group separately (women with PCOS and control women):
a
P < .05 vs AA;
b
P < .05 vs GA;
c
P < .001 vs control, adjusted for the effect of age.