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Tan IIA reduced the apoptosis rate of VSMCs and decreased the levels of MMP-2 and MMP-9 in ApoE−/− mice. (A) TUNEL assay showing decrease in TUNEL-positive cells in ApoE−/− mice treated with Tan IIA against to control group. (B,C) Western blots confirming the levels of cleaved caspase-3 or that the migration-related proteins MMP-2 and MMP-9 decreased when treated with Tan IIA in ApoE−/− mice, *P<0.05, error bars indicate that data were expressed as the mean±s.d. (n=8).
