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. 2017 Apr 1;10(4):451–461. doi: 10.1242/dmm.027623

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© 2017. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Systematic analysis of the DAT-N157K mutant rats according to the RDoC matrix. (A-C) Negative valence systems are represented as time spent freezing (calculated as percentage of the total exposure time) during footshock-conditioned (A) context and (B) cue in wild-type (WT, n=6) and DAT mutant (N157K, n=5) rats in fear-conditioning paradigm. (C) Time (s) spent in open arms by WT (n=9) and N157K (n=15) rats during a 5 min plus-maze test. (D,E) Positive valence systems are represented as (D) preference for 0.5% sucrose solution over water during the 24-h free-choice sucrose preference test in WT (n=16) and N157K (n=25) rats and as (E) number of conditioned responses during the autoshaping task in WT (n=15) and N157K (n=11) rats. In this task, the first three daily sessions consisted of 20 trials and the fourth session consisted of 40 trials. (F,G) Cognitive systems are represented as (F) time spent exploring a novel object (calculated as percentage of the total exploration time) during the novel object recognition test in WT (n=22) and N157K (n=23) rats and as (G) percentage of correct choices during the T-maze spontaneous alternation test in WT (n=5) and N157K (n=5) rats. (H,I) Systems for social processes are represented as number of (H) anogenital and non-anogenital exploration and (I) approach/following events in WT (n=12) and N157K (n=11) rats during 5 min interaction with an unknown social partner in the social interaction test. (J-L) Arousal and regulatory systems are represented as (J) circadian activity recordings in WT (n=11) and N157K (n=9) rats measured as the number of movements during five consecutive days in the home cage [black horizontal bars mark the dark (active) phases of the circadian cycle] and as locomotor vigilance measured as (K) distance travelled (m) every 10 min and as (L) total number of rearings in the 60 min open-field test in WT (n=20) and N157K (n=24) rats. All data are expressed as means±s.e.m. *P<0.05, significant difference from WT rats.