Fig. 3.

Pharmacological reversal of phenotypic alterations in DAT-N157K rats. (A,B,D,E) Distance traveled (cm) during 60 min testing in the open field in wild-type (WT, n=7-15) and DAT mutant (N157K, n=6-18) rats. Thirty minutes before the test, all rats were administered vehicle, 2 mg/kg amphetamine (A,B) or 10 mg/kg LY-341495 (D,E). The data are shown as total distance traveled (A,D) and as distance traveled every 10 min (B,E). (C,F) Extracellular DA levels in the caudate putamen of WT (n=6-7) and N157K (n=5-7) rats. At the time point 0 min, all rats were administered with the vehicle; 60 min later animals were given either 2 mg/kg amphetamine (C) or 10 mg/kg LY341495 (F). Microdialysis samples were collected every 20 min. All data are expressed as means±s.e.m. *P<0.05, significant difference from WT rats.