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. 2017 Feb 26;7(5):1062–1071. doi: 10.7150/thno.17908

Figure 3.

Figure 3

CREKA-Lipo-T treatment blocks the transition of tumor cells to EMT-like invasive cells. (A) The presence of CREKA-Lipo-T inhibited the platelet-induced invasive phenotype of 4T1 tumor cells as defined by the obvious morphological changes from polygonal to spindle-shaped cells. (B) Transwell migration assay of 4T1 tumor cells after treatment with platelets, platelets + ticagrelor, platelets + CREKA-Lipo-T, or platelets + CREKA-Lipo. (C) The data in B were quantified using image analysis software on the lower surface of the insert after crystal violet staining. Error bars represent the mean ± s.d. (n = 5); *** p<0.001.