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. 2017 Feb 26;7(5):1062–1071. doi: 10.7150/thno.17908

Figure 6.

Figure 6

Evaluation of the safety of CREKA-Lipo-T in cultured cells and in vivo. (A) The effects of various doses of CREKA-Lipo-T on the viability of 4T1, B16 and HUVEC cell lines. Error bars represent the mean ± s.d. of three independent experiments. (B) Hematological analysis. The intravenous administration of CREKA-Lipo-T into mice on 8 consecutive occasions (every two days for 16 days) had no effect on circulating red cell, white cell or platelet counts, but free ticagrelor significantly reduced the numbers in each case. Error bars represent the mean ± s.d. of three independent experiments; *p<0.05. **p<0.01. (C) CREKA-Lipo-T treatment showed no visible damage to the major organs of mice as indicated by H&E staining. Black arrows indicate blood clots (n = 3). Insert is the enlarged area.