Table 1.

Genes significantly mutated in OSCC by multiple methods.

Gene	MutSigCV (q value)	intOGen (q value)	Chi-Square (q value)	Patients number (%)
TP53	0*	0*	2.60666E-21*	52 (42.5%)
FAT1	0*	0*	0*	42 (35%)
EPHA2	0*	0*	8.83024E-40*	18 (15%)
CDKN2A	0*	0*	5.60405E-38*	21 (17.5%)
NOTCH1	0*	0*	2.27504E-21*	35 (29.17%)
CASP8	0*	0*	7.01792E-12*	28 (23.33%)
HRAS	0*	1.79995E-14*	0.779955677	14 (11.67%)
CHUK	0*	1.01941E-09*	2.892E-07*	6 (5%)
RASA1	0*	0.000329917*	2.892E-07*	6 (5%)
ELAVL1	0*	0.000715*	0.000015424*	8 (6.67%)
PIK3CA	0*	0.444915251	0.779955677	21 (17.5%)
RPTN	0*	ND	0.779955677	4 (3.33%)
ASXL1	4.73E-05*	0*	6.86368E-21*	3 (2.5%)
AHNAK	0.1394139	0.432185662	0.779955677	4 (3.33%)
CHRNB4	0.01711482*	ND	0.019808113*	4 (3.33%)
PEG3	0.1213081	ND	0.779955677	8 (6.67%)
NHSL1	0.1347749	0.002388476*	9.98024E-05*	4 (3.33%)
F2RL1	0.1347749	0.05191284*	9.98024E-05*	2 (1.67%)
VEZF1	0.1347749	0.432185662	0.019808113*	4 (3.33%)
PPM1K	0.1347749	0.467927377	0.779955677	3 (2.5%)
TRIM67	0.1394139	ND	0.019808113*	4 (3.33%)
PKP3	0.2192678	ND	0.095549499*	2 (1.67%)
PDHA2	0.3252142	ND	0.779955677	5 (4.17%)
H2BFWT	0.3399323	ND	0.265724352	2 (1.67%)
TMEM165	0.3457312	0.05191284*	0.779955677	2 (1.67%)
PTPN14	0.3468882	0.002186196*	4.32573E-07*	3 (2.5%)
PPM1D	0.3468882	0.05191284*	9.98024E-05*	2 (1.67%)
ATG4C	0.3707801	0.077115199*	0.007211938*	3 (2.5%)

*Statistically significant genes, q<0.1.