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Pharmacokinetics in SD rats after i.v. administration.
| Parameters | Dox | nBSA-Dox |
|---|---|---|
| Co (μg/mL) | 5.6 | 25.7 |
| kd (h-1) | 11.6 | 0.43 |
| t1/2, dist (h) | 0.06 | 1.6 |
| ke (h-1) | 0.95 | 0.018 |
| t1/2, elim (h) | 0.73 | 38.1 |
| Clplasma (mL h-1 g-1) | 0.85 | 0.0035 |
| AUC 0..∞ (μg h mL-1) | 5.9 | 1428.6 |
