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. 2017 Mar 23;7(5):1373–1388. doi: 10.7150/thno.17826

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Biodistribution assay. (A) Athymic nu/nu female mice were intraperitoneally injected with luciferase-expressing OVCAR8 cells. 8-day post tumor cell implantation, mice were intraperitoneally injected with Cy5-CD44-EpCAM aptamer or non-targeting control aptamers. Cy5 fluorescence of whole body was captured at the time points of 0.5h, 4h and 8h. Bioluminescence was captured at 8h post aptamer injection. (B) Ex vivo organ imaging. Following whole-body imaging, major organs were removed to be visualized the locations of aptamers (Cy5) and tumors (bioluminescence). The arrows show the co-localization of aptamer and tumors.