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Study design. The dogs were randomly assigned to duodenal infusion of either glucose or saline. After 4 h of duodenal infusion, there was a 2-h period before the clamp, followed by a 4-h hyperinsulinemic-hyperglycemic clamp with portal glucose infusion. The dogs receiving no clamp were euthanized and tissue collected at 360 min. IV, intravenous.
