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RDD in control (C) and STZ diabetic (D) rats measured 5 min after IT delivery of vehicle (Veh), 20 µg duloxetine (Dulox), or 20 µg DOI (A) or the above followed 5 min later by either ketanserin (Ket) or pruvanserin (Pruv) also at 20 μg (B). Data are group mean + SEM of N = 6–8/group. *P < 0.05, ***P < 0.001 vs. indicated group by one-way ANOVA followed by the Tukey post hoc test.
