Table 1.
Indices of diabetes and neuropathy at death in rat models of type 1 (STZ) and type 2 (ZDF) diabetes
| N | Body weight (g) | Blood glucose (mmol/L) | Blood HbA1c (%) | CSF glucose (mmol/L) | Sciatic MNCV (m/s) | Sciatic SNCV (m/s) | Thermal latency (s) | Tactile threshold (g) | |
|---|---|---|---|---|---|---|---|---|---|
| Control | 9 | 279 ± 3*** | 5.4 ± 0.1*** | 4.3 ± 0.1*** | 2.7 ± 0.2*** | 54.6 ± 1.2*** | 58.3 ± 1.6*** | 8.3 ± 0.4* | 15.0*** |
| STZ | 10 | 201 ± 4 | 27.4 ± 2.1 | 7.6 ± 0.2 | 17.1 ± 1.5 | 45.6 ± 0.9 | 47.9 ± 1.8 | 10.8 ± 0.8 | 3.1 |
| STZ + 3-OMG | 7 | 274 ± 3*** | 6.3 ± 0.3*** | 4.3 ± 0.1*** | nd | 54.3 ± 0.8*** | 55.2 ± 1.5* | 7.6 ± 0.4*** | 15.0*** |
| STZ + insulin | 6 | 259 ± 7*** | 11.9 ± 4.9** | 4.2 ± 0.3*** | 4.9 ± 1.4*** | 48.2 ± 1.0 | 55.7 ± 2.5* | 8.1 ± 0.8* | 15.0*** |
| Lean | 12 | 429 ± 4* | 9.0 ± 0.3*** | nd | nd | 56.2 ± 0.9* | 57.4 ± 2.3* | 7.1 ± 0.5** | 10.8** |
| ZDF | 9 | 380 ± 19 | 29.0 ± 1.1 | nd | nd | 53.7 ± 0.5 | 50.7 ± 1.9 | 9.9 ± 1.0 | 3.4 |
Parametric data are group mean ± SEM with statistical analysis by unpaired t test or one-way ANOVA with Dunnett post hoc test. Nonparametric data are group median with Mann-Whitney U test or Kruskal-Wallis with Dunn post hoc test. CSF, cerebrospinal fluid; MNCV, motor nerve conduction velocity; nd, not determined; SNCV, sensory nerve conduction velocity.
*P < 0.05,
**P < 0.01, and
***P < 0.001 vs. STZ or ZDF as appropriate.