Table 2.
Demographic, clinical, and neuropathy variables in control subjects and patients with and without painful diabetic neuropathy
| Control subjects (n = 15) | Painful diabetic neuropathy (n = 13) | Painless diabetic neuropathy (n = 14) | |
|---|---|---|---|
| Age (years) | 48 ± 16 | 57 ± 12 | 52 ± 17 |
| Duration of diabetes (years) | N/A | 32 ± 16 | 26 ± 19 |
| HbA1c (%) | 5.5 ± 0.4 | 7.9 ± 0.9*** | 9.1 ± 1.9*** |
| NDS (0–10) | 0.1 ± 0.2 | 3.3 ± 1.5** | 3.1 ± 1.4** |
| NSP (0–38) | 0.1 ± 0.2 | 6.6 ± 3.5***++ | 2.4 ± 2.1* |
| VPT (V) | 5.7 ± 5.7 | 18.3 ± 13*** | 16.8 ± 11.4*** |
| Cold perception threshold (°C) | 28.8 ± 2.0 | 23.4 ± 5.3** | 26.1 ± 3.5** |
| Warm perception threshold (°C) | 37.2 ± 2.5 | 42.3 ± 4.0** | 40.6 ± 4.0* |
| SSamp (µV) | 18.7 ± 9.6 | 6.6 ± 4.6** | 10.8 ± 7.7** |
| SSCV (m/s) | 51.7 ± 3.1 | 40.6 ± 7.9*** | 42.2 ± 6.2*** |
| PMamp (mV) | 5.9 ± 2.0 | 1.9 ± 1.2*** | 2.8 ± 2.3** |
| PMCV (m/s) | 49.9 ± 4.4 | 37.8 ± 6.9*** | 38.9 ± 8.4*** |
| H-reflex latency (ms) | 32.4 ± 3.9 | 37.1 ± 3.7** | 36.1 ± 3.3* |
| H-reflex amplitude (µV) | 2,024.7 ± 596.0 | 959.2 ± 927.3 | 1,071.4 ± 957.9 |
| IENFD (no./mm) | 10.6 ± 4.0 | 4.2 ± 1.5* | 4.9 ± 3.1** |
| CNFD (no./mm2) | 33.7 ± 8.6 | 16.6 ± 8.0***+ | 24.7 ± 7.4* |
| CNFL (mm/mm2) | 25.6 ± 6.3 | 13.6 ± 6.2*** | 18.1 ± 5.5** |
| CNBD (no./mm2) | 91.3 ± 41.4 | 35.6 ± 1.4*** | 47.4 ± 26.7** |
Results are expressed as mean ± SD. N/A, not applicable. Statistically significant differences identified with the Kruskal-Wallis test followed by Dunn post hoc test for multiple comparisons:
*P < 0.05,
**P < 0.01, and
***P < 0.001 for control subjects against diabetic neuropathy groups;
+P < 0.05 and ++P < 0.01 for painful diabetic neuropathy against painless diabetic neuropathy.