TABLE 3.
Comparison of NCA pharmacokinetic parameters based on total NPX concentrations for 50 mg/kg i.p. doses in CIA and healthy rats
Values are mean ± S.D.
| Groups | n | AUC |
CL/F |
V/F |
t1/2 |
|---|---|---|---|---|---|
| µg∣h/ml | ml/h/kg | ml/kg | h | ||
| CIA males | 3 | 809.8 ± 61.0* | 61.99 ± 4.87** | 229.3 ± 48.9* | 2.55 ± 0.36 |
| Healthy males | 4 | 1054.5 ± 116.5 | 47.76 ± 4.98 | 169.7 ± 18.2 | 2.46 ± 0.03 |
| CIA females | 3 | 936.0 ± 42.2* | 53.43 ± 2.53* | 287.1 ± 42.5* | 3.74 ± 0.64 |
| Healthy females | 4 | 1203.4 ± 138.2 | 41.89 ± 4.51 | 188.6 ± 24.7 | 3.13 ± 0.34 |
*
P < 0.05; **P < 0.01 (significant difference compared with healthy group in each sex group).