TABLE 4.
Modeled pharmacokinetic parameter estimates for unbound NPX after i.p. administration
| Parameters | Definition | Estimates | CV% |
|---|---|---|---|
| ka (1/h) | Absorption rate constant | 0.814 | 7.54 |
| CLArthritic (ml/h/kg) | Unbound plasma clearance in arthritic rats | 1370 | 4.73 |
| CLHealthy (ml/h/kg) | Unbound plasma clearance in healthy rats | 1879 | 9.26 |
| Vp (ml/kg) | Central volume of distribution | 32.36a | Fixed |
| CLdArthritic (ml/h/kg) | Unbound distribution clearance in arthritic rats | 647.2 | 18.61 |
| CLdHealthy (ml/h/kg) | Unbound distribution clearance in healthy rats | 1371 | 45.23 |
| VtArthritic (ml/kg) | Peripheral distribution volume in arthritic rats | 140.7 | 9.27 |
| VtHealthy (ml/kg) | Peripheral distribution volume in healthy rats | 114.7 | 17.37 |
a
Physiologic parameter values obtained from Shah and Betts (2012).