Fig. 2.

Model fittings of NPX plasma concentration versus time profiles (A and B) and fitted total and unbound NPX concentrations in plasma (solid lines) and ISF (dashed lines) (C–F) in female (left) and male (right) arthritic rats that received 50-mg/kg intraperitoneal doses of NPX. Symbols are total plasma concentration measurements and curves depict model fittings or predictions. The inset figure is the comparison of unbound ISF NPX concentrations in CIA females (dashed line) and males (solid line).