TABLE 1.
Pharmacokinetic parameter estimates for NPX in healthy and CIA rats after intraperitoneal administration
| Parameter | Definition | Estimate | CV% |
|---|---|---|---|
| ka (l/h) | Absorption rate constant | 0.98 | 8.3 |
| fd | Fraction of cardiac plasma flow | 0.15 | 12.9 |
| CLArthritic (ml/h per kg) | Unbound plasma clearance in arthritic rats | 1438 | 3.2 |
| CLHealthy (ml/h per kg) | Unbound plasma clearance in healthy rats | 1968 | 5.3 |
| Vp (ml/kg) | Plasma volume | 32.36a | Fixed |
| Vt (ml/kg) | ISF volume | 173.93a | Fixed |
| Qco (ml/h per kg) | Cardiac plasma flow | 7650a | Fixed |
a
Physiologic parameter values obtained from Shah and Betts (2012).