Figure 1. Basal hypothalamic neuronal activity is depressed in 8 month old Ins2^Akita mice.

A) Averaged signal intensity maps (MEMRI) plotted on real brain atlas transverse sections in the central hypothalamus (PVN region). Upper row: averaged signal intensity maps from 2 month old Ins2^Akita mice (right), and 2 month old controls (left) showing little differences in most regions. Lower row: averaged signal intensity maps from 8 month old Ins2^Akita mice (right) and 8 month old controls (left) showing relative hypothalamic and PVN depression in Ins2^Akita mice. B) Bar chart showing quantification of normalized signal intensity for the entire hypothalamus and the PVN region (C) in all 4 experimental conditions.