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. 2017 Mar;12(3):425–432. doi: 10.4103/1673-5374.202946

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Effects of STL on the protein expression of SIRT1, Ac-p53, Bcl-2 and Bax in the brain 24 hours after cerebral I/R.

(A) Western blot assay for protein expression in each group. (B–E) Density analysis of SIRT1 (B), Ac-p53 (C), Bcl-2 (D), and Bax (E) protein expression. β-Actin was used as a loading control. The protein expressions were expressed as the optical density percentage of the target protein to β-actin. Values are expressed as the mean ± SEM (n = 4 rats per group), and were analyzed by analysis of variance followed by the least significant difference test. **P < 0.01, vs. sham group; ##P < 0.01, vs. I/R group; &&P < 0.01, vs. I/R + STL (17.2 mL/kg) group. STL: Shuan-Tong-Ling; I/R: ischemia/reperfusion; Ac-p53: acetylated-protein 53; EX527: SIRT1 inhibitor; SIRT1: silent information regulator 1.