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. 2017 Mar;12(3):464–469. doi: 10.4103/1673-5374.202925

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Effects of estrogen on the CCI-induced changes in PWMT and PWTL.

PWMT (A) and PWTL (B) of rats in the five treatment groups at various times after nerve injury. Data are expressed as the mean ± SD from 10 rats in each group (one-way analysis of variance and Student-Newman-Keuls test). Data are calculated by using the results of three measurements. *P < 0.05, **P < 0.01, vs. sham-operated group; #P < 0.05, vs. CCI group. Sham-operated group: Exposed sciatic nerve without ligation. Estrogen group: CCI surgery + 2 μL/day 17β-estradiol injected subcutaneously. AP-5 group: CCI surgery + 100 nmol/day AP-5 injected subcutaneously. Estrogen + AP-5 group: CCI model + 2 μL/day 17β-estradiol + 100 nmol/day AP-5 injected subcutaneously. T0–T4: 1 day before surgery and 1, 3, 7, 14 days after surgery, respectively. CCI: Chronic constriction injury; AP-5: D(-)-2-amino-5-phosphonopentanoic acid; PWMT: paw withdrawal mechanical threshold; PWTL: paw withdrawal thermal latency.