FIG. 4.
Glucose-sensing cannula results obtained in anesthetized nondiabetic swine. An example data set for an H2O2-sensing electrode during lis-pro insulin delivery is shown in the upper panel. Note very high spurious response to the insulin formulation. All individual data sets for this condition are shown in Supplementary Figures 1–6 (available at www.liebertonline.com/dia). The lower panel shows mean data for redox sensor cannulae during lis-pro insulin delivery—no such spurious rise in current was noted in these devices. In these experiments, glucose was clamped at euglycemia until minute 200, at which time hyperglycemia was induced by dextrose infusion. The infusion was then stopped to monitor the fall of the sensor signal. The arrow indicates the insulin bolus.