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The Qβ RNAi scaffold is designed to fold into two hairpins and co-assemble with CP in vivo. A single RNA molecule forms the Qβ hairpin (blue) linked to a miR-30B stem loop (green), which contains the functional RNA duplex (yellow/red). The functional RNA duplex can encode miRNA or siRNA. The scaffold can incorporate any 22 base pair sequence, depending on the desired target. (A) An RNAi scaffold that targets GFP mRNA. (B) An RNAi scaffold that targets the Pan-Ras mRNA 3΄ UTR.
