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. 2017 Apr 21;14:13. doi: 10.1186/s12989-017-0193-5

Fig. 4.

Fig. 4

Safety assessment of EDTMP coated MOx in animal lungs. a Differential cell counts in BALF, b LDH and cytokine release in BALF, c H&E staining of lung sections from MO-exposed mice. TiO2, CuO, EDTMP-CuO, Co3O4 or EDTMP-Co3O4 were oropharyngeally administrated at 2 mg/kg (6 mice in each group), while animals received 5 mg/kg quartz exposure were used as positive control. After 40 h, animals were sacrificed to analyze LDH (upper left panel), MCP-1 (upper right panel), LIX (lower left panel) and IL-6 (lower right panel) production in BALF. * p < 0.05 compared to uncoated MOx