Table 6.
Patient Global Impression of Change (PGIC) responses
| Response | Patients, n (%) | ||
|---|---|---|---|
| First treatment | Second treatment | Third treatment | |
| Week 2 | n = 408 | ||
| Improved | 258 (63.2) | ||
| No change | 117 (28.7) | ||
| Worsened | 33 (8.1) | ||
| Week 8 | n = 368 | ||
| Improved | 231 (62.8) | ||
| No change | 110 (29.9) | ||
| Worsened | 27 (7.3) | ||
| Week 12 | n = 367 | n = 150 | n = 47 |
| Improved | 224 (61.0) | 112 (74.7) | 37 (78.7) |
| No change | 116 (31.6) | 30 (20.0) | 8 (17.0) |
| Worsened | 27 (7.4) | 8 (5.3) | 2 (4.3) |
| Week 26 | n = 207 | n = 101 | n = 28 |
| Improved | 113 (54.6) | 67 (66.3) | 23 (82.1) |
| No change | 76 (36.7) | 26 (25.7) | 3 (10.7) |
| Worsened | 18 (8.7) | 8 (7.9) | 2 (7.1) |
| Week 39 | n = 177 | n = 81 | n = 21 |
| Improved | 96 (54.2) | 50 (61.7) | 18 (85.7) |
| No change | 65 (36.7) | 24 (29.6) | 1 (4.8) |
| Worsened | 16 (9.0) | 7 (8.6) | 2 (9.5) |
| Week 52 | n = 176 | n = 56 | n = 7 |
| Improved | 93 (52.8) | 38 (67.9) | 5 (71.4) |
| No change | 71 (40.3) | 14 (25.0) | 1 (14.3) |
| Worsened | 12 (6.8) | 4 (7.1) | 1 (14.3) |
Improved: slightly, much, very much; Worsened: slightly, much, very much