Fig. 3.

Suppression of Soraphen A toxicity. The acc1^cs mutant (H-470) is extremely sensitive to Soraphen A, a potent inhibitor of AcCoA carboxylase, even at the permissive temperature of 30°C. This growth defect is effectively suppressed by the acc1^cs suppressor strains R3, R34, R64 and, to a lesser extent, R92. The plate was photographed after 2 days incubation at 30°C. Note: The H-470 (acc1^cs) sensitivity to Soraphen A is at 30°C, identical to the Csm⁻ phenotype of H-470 in the absence of Soraphen A at 16°C (Fig. 1).