Figure 6. Orexin induced metabolic respiration is directly mediated by orexin receptors.
Oxygen consumption rates (OCRs) were determined in mHypoA-1/2 cells treated with OXA (300 nM) and/or DORA (1.16 nM) for 2 h. OXA increases B) basal respiration (p<0.0001 vs. C), C) ATP turnover (p>0.001 vs. C), D) maximum respiration (p<0.0001 vs. C), and E) reserve capacity (p<0.05 vs. C). Treatment with DORA attenuates OXA-increased B) basal respiration (p<0.0001 vs. OXA), C) ATP turnover (p<0.0001 vs. OXA), D) maximum respiration (p<0.0001 vs. OXA), and E) reserve capacity (p<0.0001 DORA vs. OXA, p<0.001 OXA+DORA vs. OXA).