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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Mol Cell Neurosci. 2016 Jul 21;75:93–100. doi: 10.1016/j.mcn.2016.07.003

Figure 7. Orexin stabilizes metabolic respiration.

Figure 7

Oxygen consumption rates (OCRs) were determined in mHypoA-1/2 cells pretreated with OXA (300 nM) for 24 h and challenged with PA in the presence or absence of OXA for 6 h. PA significantly reduces B) basal respiration (p<0.0001 vs. C, OXA, OXA+PA), C)ATP turnover (p<0.0001 vs. C, OXA, p<0.001 vs. OXA+PA), D) maximum respiration (p<0.0001 vs. OXA, p<0.001 vs. C, OXA+PA), and E) reserve capacity (p<0.05 vs. C, OXA+PA, p<0.0001 vs. OXA). Treatment with OXA stabilizes PA-reduced B) basal respiration, C) ATP turnover, D) maximum respiration, and E) reserve capacity.