Table 3.
Impact of Different Simulated Treatment Strategies Based on Positive RDT and Serological Screening Results
| Treatment Strategy | Persons Treated, % |
PCR-Positive Infections Treated, % |
Mosquito Infections Avoided, %a |
|---|---|---|---|
| All RDT-positive individuals | 0.2 | 8.9 | 28.2–44.7 |
| All members of households with ≥1 RDT-positive individual | 1.0 | 13.0 | 31.4–52.2 |
| All living within given radius of RDT-positive individual | |||
| <100 m | 4.4 | 16.2 | 34.0–53.9 |
| <300 m | 13.9 | 30.1 | 44.9–61.5 |
| <1000 m | 57.6 | 65.9 | 73.1–81.2 |
| All individual with positive results | |||
| AMA | 19.6 | 45.7 | 47.9–50.3 |
| MSP-119 | 14.7 | 41.1 | 41.8–42.6 |
| AMA or MSP-119 | 26.4 | 56.8 | 62.0–66.9 |
| All members of households with | |||
| ≥1 AMA-positive individual | 49.9 | 67.0 | 71.9–77.2 |
| ≥1 MSP-119–positive indivudal | 41.6 | 61.0 | 64.7–68.8 |
| ≥1 AMA- or MSP-119–positive individual | 62.8 | 76.8 | 82.6–88.1 |
Abbreviations: PCR, polymerase chain reaction; RDT, rapid diagnostic test.
aShown as range, with lower estimates assuming infectivity rates in reference [7] and higher estimates according to reference [31].