Table 2.
The concentrations of TAM and its metabolites (ng/mL) among different CYP2D6 polymorphisms
| CYP2D6 | n | TAM | NDMT | END | 4OHT |
|---|---|---|---|---|---|
| Genotype | 133 | p=0.122 | p=0.078 | p=0.226 | p=0.491 |
| CYP2D6*1/*1 | 13 | 429.6 (266.5) | 948.5 (466.0) | 69.9 (71.8) | 5.9 (9.0) |
| CYP2D6*1/*10 | 21 | 324.7 (239.5) | 997.8 (741.6) | 61.2 (79.9) | 6.5 (3.4) |
| CYP2D6*10/*10 | 72 | 375.5 (231.9) | 1,095.8 (597.4) | 51.1 (46.0) | 4.5 (2.5) |
| CYP2D6*2/*2 | 5 | 355.7 (171.2) | 1,085.9 (838.9) | 56.2 (51.2) | 4.6 (2.5) |
| CYP2D6*2/*10 | 13 | 283.3 (174.9) | 994.6 (462.0) | 46.3 (57.3) | 5.4 (3.1) |
| CYP2D6*1/*2 | 3 | 481.7 (0.0) | 1,170.9 (0.0) | 113.5 (0.0) | 5.1 (0.0) |
| CYP2D6*4/*4 | 2 | 238.4 (0.0) | 803.2 (0.0) | 41.9 (0.0) | 6.2 (0.0) |
| CYP2D6*4/*10 | 4 | 486.5 (138.7) | 1,924.6 (730.5) | 48.2 (29.4) | 7.0 (9.6) |
| Phenotype | 133 | p=0.031* | p=0.052 | p=0.128 | p=0.156 |
| EM | 55 | 373.1 (224.7) | 1,031.0 (503.6) | 64.8 (69.3) | 5.8 (3.3) |
| IM | 76 | 382.9 (232.5) | 1,113.1 (612.0) | 50.4 (43.5) | 4.6 (3.2) |
| PM | 2 | 238.4 (0.0) | 803.2 (0.0) | 41.9 (0.0) | 6.2 (0.0) |
Note: The concentrations of TAM and its metabolites are presented as median (interquartile range). p=p value from Kruskal–Wallis test,
*
p<0.05.
Abbreviations: 4OHT, 4-hydroxytamoxifen; EM, extensive metabolizer; END, endoxifen; IM, intermediate metabolizer; NDMT, N-desmethyl tamoxifen; PM, poor metabolizer; TAM, tamoxifen.