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Simulated Sintra as a function of cell diameter (i.e., 2·rcell). (a) Sintra with no exchange (Pce = 0) and corresponding fitted values for (b) AR2intra, and (c) ADCintra. (d) Sintra allowing for exchange with the extracellular compartment Pce = 0.003 μm/ms. Simulations parameters: ν = 0.4, b = 4000 s/mm2, TE = 140 ms, δ = Δ = [12,18,24,30,36,42,48,54,60] ms. Black lines indicate clinically relevant parameters.
