Figure 3.

Administration of SPRM, UPA, modulates sex-steroid receptor localization. Representative immuno-localization of progesterone receptor (PR; A–D), PRB (E–H), androgen receptor (AR; I–L) and estrogen receptor alpha (ERα; M–P) in endometrium from woman with fibroids during proliferative and secretory stages and after UPA administration. Subject A shows endometrium in which PAEC are characterized by extensive cystic glandular dilatation; Subject I has PAEC with minimal cystic change. Neither subject had evidence of submucosal fibroids, and both women described amenorrhoea on UPA treatment. Samples from UPA-treated women displayed intense immunopositive (+ = positive and − = negative) glandular nuclei with only a few immunopositive cells in the stroma, a result in contrast with proliferative phase (G+S+) or secretory phase (G−S+).  ×40 magnification (scale bar = 50 µm); G, Glands; S, Stroma. Negative controls shown as inserts on secretory endometrium.