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SPRM, UPA, administration does not increase endometrial cell proliferation. Proliferation assessed by Ki67 immunohistochemistry (A–D) and stereological quantification (E–G). Subject A shows endometrium in which PAEC are characterized by extensive cystic glandular dilatation; Subject I has PAEC with minimal cystic change. ×40 magnification (scale bar = 50 µm); G: Glands, S: Stroma. Kruskal–Wallis statistical test *P < 0.05; **P < 0.01.
