Table 1.
MICs for and mutations of MDR-TB baseline clinical isolates
| Rv0678 locus | Number of isolates with bedaquiline MIC (mg/L) |
Total | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1.000 | 0.480 | 0.240 | 0.120 | 0.060 | 0.030 | 0.015 | 0.007 | 0.004 | ||
| Non-silent mutation | 1 | 5 | 2 | 3 | 1 | 1 | 13 | |||
| WT + non-silent mutation | 1 | 1 | 3 | 1 | 6 | |||||
| WT + non-silent mutation + mutation in position −11 | 2 | 2 | ||||||||
| WT + non-silent mutation + silent mutation | 1 | 1 | ||||||||
| Non-silent mutation + mutation in position −13 | 1 | 1 | ||||||||
| Intergenic mutation in position −11 or intergenic mutation in position −11 + Rv0678 silent mutation | 7 | 28 | 2 | 37 | ||||||
| Intergenic mutation, not −11 | 1 | 1 | 2 | |||||||
| Silent mutations or mixture of WT + silent | 1 | 2 | 1 | 4 | ||||||
| WT | 2 | 48 | 153 | 69 | 7 | 2 | 281 | |||
| Total analysed | 2 | 6 | 5 | 53 | 160 | 78 | 37 | 1 | 5 | 347 |
The numbers of isolates with high (> 0.24 mg/L), normal (0.03–0.24 mg/L) and low (< 0.03 mg/L) bedaquiline MICs are indicated for every type of mutation in the Rv0678 gene and the intergenic region mmpS5–Rv0678 .
Non-silent mutations refer to non-synonymous mutations and small insertions or deletions in the Rv0678 coding region.